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KMID : 0358320080490040366
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Korean Journal of Urology
2008 Volume.49 No. 4 p.366 ~ p.372
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The Effects of Vasopressin and Desmopressin on the Contractile and Relaxation Responses of Rabbit Cavernosal Smooth Muscle
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Shin Hyung-Oh
Myung Soon-Chul
Kim Sae-Chul
Lee Moo-Yeol
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Abstract
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Purpose : This study aimed to investigate the effects of vasopressin and desmopressin on the contractile and relaxative responses of rabbit cavernosal smooth muscle.
Materials & Methods : Isometric tension studies were conducted to investigate the effects of vasopressin(10?14-10?8M) and desmopressin(10?14- 10?8M) on the contraction and relaxation responses of rabbits cavernous muscle strips in an organ bath. The effects of pretreatment with phenylephrine(10?5M), L-NAME(10?5M) and indomethacin(10?5M) on the contraction and relaxation responses of the vasopressin and desmopressin were also investigated. The statistics were analyzed by Student’s t-test and ANOVA.
Results : Vasopressin contracted the strips in a dose-dependent manner, while desmopressin did not. The phenylephrine-induced contraction was dose-dependently increased by vasopressin, but it was dose-dependently relaxed by desmopressin. L-NAME pre-treatment did not block the relaxation response, but indomethacin pre-treatment did. Vasopressin- induced contraction occurred the via V1 receptor, while desmopressin- induced relaxation occurred via the V2 receptor.
Conclusion : Vasopressin, in pathophysiological circumstances, would worsen erectile dysfunction. On the contrary, desmopressin, which may induce an endothelium-dependent relaxation of the cavernous smooth muscles, would be good for erectile function. (Korean J Urol 2008;49: 366-372)
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KEYWORD
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Vasopressins, Desmopressin, Cavernosal smooth muscle, Contraction, Relaxation
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